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Journal of Pharmacology And Experimental Therapeutics, Vol. 150, Issue 3, 463-468, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

METABOLISM OF DIGOXIN: ROLE OF THE LIVER IN TRITIATED DIGOXIN DEGRADATION

Ronald M. Abel 1, Robert J. Luchi 1, Gerald W. Peskin 1, Hadley L. Conn Jr. 1, and Leonard D. Miller 1

1 Department of Medicine and the Edward S. Robinette Foundation, Hospital of the University of Pennsylvania, and the Harrison Department of Surgical Research of the School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania

The effect of circulatory bypass of the liver on the metabolism of tritiated digoxin was determined in seven dogs. Thin-layer chromatographic techniques were used in the separation of digoxin from its metabolites. Although the metabolism of digoxin was retarded following liver bypass, significant extrahepatic metabolism was observed under both control and bypass conditions.

Accepted on July 13, 1965






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