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Journal of Pharmacology And Experimental Therapeutics, Vol. 150, Issue 2, 328-334, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

SOME DETAILS OF THE INFLAMMATIONS CAUSED BY YEAST AND CARRAGEENIN (WITH APPENDIX ON KINETICS OF THE REACTION)

C. G. Van Arman 1, A. J. Begany 1, L. M. Miller 1, and H. H. Pless 1

1 Pharmacological Evaluation Section, Wyeth Laboratories, Radnor, Pennsylvania

An improved assay method for inflammation in the rat’s foot is described. Bradykinin, histamine, serotonin, yeast and carrageenin were investigated. The kinetics of yeast-induced swelling were determined, and an equation was found that enables prediction of the swelling as a function of time and dosage. Similar work with carrageenin was done at a fixed dose. Evidence was obtained that for yeast inflammation, the mast cell may be involved, but for carrageenin inflammation no such clear evidence was found. Carrageenin can be blocked by soybean trypsin inhibitor, and therefore presumably acts through a proteolytic process. Bradykinin may be a mediator of this process.

Accepted on June 10, 1965




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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.