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Journal of Pharmacology And Experimental Therapeutics, Vol. 150, Issue 2, 322-327, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

THE DISTRIBUTION, EXCRETION AND METABOLISM OF HYDROXYUREA-C14

Richard H. Adamson 1, Sara L. Ague 1, Sidney M. Hess 1, and Jack D. Davidson 1

1 Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, and The Squibb Institute for Medical Research, New Brunswick, New Jersey

The fate of radioactive hydroxyurea (HU-C14) has been studied in mice and rats following single parenteral and oral doses.

One-half hour after parenteral administration in mice, radioactivity was present in all tissues and organs examined but was predominant in the kidneys and bladder with contents.

Following parenteral dosage at two levels, three-fourths of the radioactivity was recovered in the urine with trace amounts in the feces after 24 hours. No difference in excretion pattern was noted following oral administration.

In rats, similar results were obtained following parenteral administration.

Urine samples were analyzed by high-voltage paper electrophoresis and an adaptation of the Fearon carbamido reaction to the Technicon AutoAnalyzer. Urea-C14 and C14O2 were identified as metabolites of HU-C14 in mouse urine.

In vitro experiments determined that mouse liver and kidney minces were able to convert HU-C14 to urea-C14.

Accepted on May 26, 1965




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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.