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Journal of Pharmacology And Experimental Therapeutics, Vol. 150, Issue 2, 236-243, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF METHYL, ETHYL AND n-PROPYL ALCOHOL ON NEUROMUSCULAR TRANSMISSION IN THE RAT

P. W. Gage 1

1 Department of Physiology, John Curtin School of Medical Research, Australian National University, Canberra, Australia

The action of ethyl alcohol on neuromuscular transmission in rats was studied in both curarized and magnesium-blocked preparations. Ethyl alcohol in concentrations above 8 mM caused an increase in the amount of transmitter released by a nerve impulse. At higher concentrations the spontaneous release of transmitter was also increased. In addition to the presynaptic action, the depolarizing action of the transmitter on the postsynaptic membrane was enhanced; this effect was not prevented by an anticholinesterase. Ethyl alcohol increased the "input" resistance of rat diaphragm muscle membrane and it is proposed that this increase in resistance is the cause of part of the increased postsynaptic effect of the transmitter. Methyl and n-propyl alcohol also increased transmitter release and raised the sensitivity of the postsynaptic membrane to the transmitter. The isometric twitch tension in curarized toad sartorii directly stimulated was decreased by ethyl alcohol. This effect was interpreted as a decrease in muscle contractility.

Accepted on May 27, 1965




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