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Journal of Pharmacology And Experimental Therapeutics, Vol. 150, Issue 1, 53-56, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

DIGITALIS-LIKE SUBSTANCES OF ANTIARIS

K. K. Chen 1 and F. G. Henderson 1

1 Department of Pharmacology, Indiana University School of Medicine, and Lilly Research Laboratories, Indianapolis, Indiana

Four glycosides of the tree sap, and four of the seeds of Antiaris toxicaria, and three of their chemically modified products, have been studied in frogs and cats. They all show a digitalis-like effect on the heart. Assays in cats anesthetized with ether reveal that the natural glycosides are highly potent.

Accepted on May 17, 1965






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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.