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Journal of Pharmacology And Experimental Therapeutics, Vol. 150, Issue 1, 34-40, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

EVALUATION OF VARIOUS ADRENERGIC BLOCKING AGENTS IN ISOLATED RABBIT AND TURTLE HEARTS

Walter D. Meester 1, Harold F. Hardman 1, and Joseph J. Barboriak 1

1 Department of Pharmacology, Marquette University School of Medicine and Research Service, Wood V. A. Center, Milwaukee, Wisconsin

The effects of various adrenergic blocking agents on the cardiac positive inotropic action of epinephrine were studied in isolated perfused rabbit and turtle hearts. Some of the newer adrenergic blocking agents, including pronethalol (PRON), the N-isopropyl and n-butyl derivatives of p-nitrophenylethanolamine (INPEA and BNPEA, respectively) and N-isopropylmethoxamine (IMA) were compared with dichloroisoproterenol (DCI).

It was found that under the conditions of this study, all of these agents possess beta adrenergic receptor blocking activity in rabbit and turtle hearts. DCI and pronethalol were approximately equieffective and superior in their blocking ability to the other compounds tested. INPEA provided better blockade of the positive inotropic action of epinephrine than BNPEA and IMA, both of which possessed only weak beta blocking action.

Accepted on April 21, 1965




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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.