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Journal of Pharmacology And Experimental Therapeutics, Vol. 150, Issue 1, 23-25, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

EVIDENCE FOR BETA RECEPTORS IN THE RAT MESENTERIC MICROVASCULATURE

Burton M. Altura 1 and Benjamin W. Zweifach 1

1 Departments of Anesthesiology and Pathology, New York University School of Medicine, New York, New York

Experiments were designed to establish the effect of dichloroisoproterenol (DCI) on the peripheral microvasculature of the rat mesocecum. The microcirculatory effects of DCI were documented by direct microscopic visualization of the response to locally applied catecholamines, as well as histamine and serotonin.

Administration of DCI (10 mg/kg) produced a marked transient venular constriction (which disappeared in 2 to 5 minutes) and an increase in vascular reactivity to locally applied constrictor catecholamines while blocking the local vasodilator action of isoproterenol.

On the basis of time selective blockade, by DCI, of the dilator effects of isoproterenol andtime enhancement of venular constrictor action in comparison to time amount of arteriolar constriction to locally applied epinephrine and norepinephrine, it is concluded that beta type receptors exist in the rat mesenteric microcirculation.

Accepted on May 3, 1965






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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.