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1 Department of Pharmacology, Albert Einstein College of Medicine, New York, N. Y., and the Department of Biochemistry, Geigy Research Laboratories, Ardsley, New York
A comparison has been made of the effect of the nerve sheath on the action of local anesthetics in three different types of nerve fiber preparations, namely, mammalian myelinated, mammalian nonmyelinated and amphibian myelinated nerve fibers.
In all types of fiber, alkaline anesthetic solutions were more effective in sheathed preparations, and neutral anesthetic solutions were more effective in desheathed preparations.
These results have confinned our earlier conclusion that the cation is the active form of local anesthetics and that the uncharged molecule is important only for penetration to the receptor site.
Accepted on May 7, 1965
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