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Journal of Pharmacology And Experimental Therapeutics, Vol. 150, Issue 1, 140-145, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

THE RAPID DEVELOPMENT OF PHYSICAL DEPENDENCE ON BARBITURATES

Jerome H. Jaffe 1 and Seth K. Sharpless 1

1 Department of Pharmacology, Albert Einstein College of Medicine, New York, New York

Thresholds for pentylenetetrazol-induced seizures were determined in cats after varying periods of deep barbiturate intoxication. Thresholds measured 18 to 22 hours after the last dose of barbiturate were significantly decreased even with the shortest period of barbiturate intoxication employed (26 hr). This decrease was interpreted as a manifestation of barbiturate withdrawal. Spontaneous seizures were seen during the withdrawal period after as little as 2 weeks of intoxication.

The time course of the development of physical dependence was compared to the time course of the development of denervation supersensitivity in peripheral structures.

Accepted on April 23, 1965






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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.