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Journal of Pharmacology And Experimental Therapeutics, Vol. 150, Issue 1, 135-139, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

TEMPERATURE RESPONSES IN THE RAT FOLLOWING INTRACEREBRAL MICROINJECTION OF MORPHINE

V. J. Lotti 1, Peter Lomax 1, and R. George 1

1 Department of Pharmacology, The Center for the Health Sciences and Brain Research Institute, University of California, Los Angeles, California

The effect of morphine sulfate on the body temperature of the rat has been investigated. With a dose of 10 mg/kg administered intravenously there occurred a marked fall in core temperature and the degree and duration of hypothermia increased to give a maximum response with 35-50 mg/kg. Doses of 1 and 5 mg/kg caused either no change or a rise in temperature.

Injection of 50 µg morphine sulfate into the region of the preoptic/anterior hypothalamic nuclei also led to a fall in core temperature, while injections into other regions of the hypothalamus were ineffective. Introduction of the drug into the area of the mammillary nuclei caused hyperactivity and hyperthermia.

It is suggested that the hypothermic effect of morphine is due to depression of the set point of the thermoregulatory center in the anterior hypothalamus.

Accepted on May 18, 1965




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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.