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Journal of Pharmacology And Experimental Therapeutics, Vol. 150, Issue 1, 105-108, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

METABOLIC FATE OF BENZYL N-BENZYL CARBETHOXYHYDROXAMATE (W-398)

J. F. Douglas 1

1 Wallace Laboratories, Division of Carter Products, Inc., Cranbury, New Jersey

The metabolic fate of benzyl N-benzyl carebthoxyhydroxamate, W-398, was investigated in the rat and rabbit Utilizing W-398 tagged separately in several positions with C14. In the rat the carbonyl carbon is converted to respiratory carbon dioxide while the benzyl groups are oxidized to benzoic acid. Most of the latter is conjugated with glycine and excreted in the urine as hippuric acid and a small amount is excreted as unchanged benzoic acid. No unchanged W-398 could be detected in the urine of drug-fed rats.

The rabbit also metabolizes W-398 to benzoic acid which is excreted partly unchanged and partly as hippuric acid. Two additional metabolites were present in the urine of rabbits receiving labeled W-398.

Accepted on May 7, 1965






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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.