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Journal of Pharmacology And Experimental Therapeutics, Vol. 15, Issue 5, 453-473, 1920
Copyright © 1920 by American Society for Pharmacology and Experimental Therapeutics

QUANTITATIVE STUDIES IN CHEMOTHERAPY I. THE TRYPANOCIDAL ACTION OF ANTIMONY COMPOUNDS

CARL VOEGTLIN 1, HOMER W. SMITH 1, MARIAN M. CRANE 1, KATHERINE D. WRIGHT 1, and MABEL A. CONNELL 1

1 From the Division of Pharmacology, Hygienic Laboratory, United States Public Health Service

1. The specific action of the antimonyllactate on the trypanosomes of infected rats can be studied fairly accurately by following the disappearance of the parasites from the bloodstream.

2. A sharply defined threshold (minimum effective dose) is observed, below which the drug has no appreciable effect upon the parasites. This threshold is in part due to the nature of the reaction between the drug and the parasites, and in part to absorption of the drug by the tissues of the host.

3. The process curve is an orderly one, and consistent throughout individual experiments. However, various experiments indicate two general types of reactions, differing in reaction velocity. In one type the reaction velocity remains constant throughout the experiment. In the other, the reaction velocity is constantly increasing.

4. A method for the rapid and accurate determination of the trypanocidal power of drugs (minimum effective dose) is recommended.

Submitted on May 11, 1920






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Copyright © 1920 by the American Society for Pharmacology and Experimental Therapeutics.