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Journal of Pharmacology And Experimental Therapeutics, Vol. 15, Issue 2, 95-103, 1920
Copyright © 1920 by American Society for Pharmacology and Experimental Therapeutics

AN APPARATUS FOR THE EXPOSURE OF SKIN OR MUCOUS MEMBRANE TO THE VAPOR OF TOXIC SUBSTANCES, WITH OBSERVATIONS ON DICHLORETHYLSULPHIDE

J. A. E. EYSTER 1 and MARY E. MAVER 1

1 From the Laboratories of the Wisconsin Section, Medical Division, Chemical Walfare Service

An apparatus is described by means of which the skin or mucous membranes may be exposed to accurately controlled concentrations of toxic vapors under conditions simulating the presence of such vapors free in the atmosphere. Data is included on the skin toxicity of dichlorethylsulphide on rabbits and on man and on the toxicity of the vapors to the rabbit's eye, in order to illustrate the method of use and applicability of the apparatus. This data suggest the necessity of determinations on man when human toxicity determination is desired in the study of other irritant vapors.

Submitted on December 21, 1919






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