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Journal of Pharmacology And Experimental Therapeutics, Vol. 15, Issue 2, 129-134, 1920
Copyright © 1920 by American Society for Pharmacology and Experimental Therapeutics

THE LOCAL ANESTHETIC PROPERTIES OF PHENYL METHYL CARBINOL

AXEL M. HJORT 1 and CHARLES E. KAUFMANN 1

1 From the Department of Pharmacology, Yale University School of Medicine

1. The following table serves best to compare the physiological activity of phenyl methyl carbinol with that of benzyl alcohol and rose oil:

2. dl phenyl methyl carbinol is a more potent local anesthetic on the rabbit's cornea and in the human skin than either its isomer rose oil or their homologue benzyl alcohol, but not in proportion to its greater toxic action.

3. The relative instability of the agr-phenethylol offers further objection to its practical application.

4. The increased physiological action may be due to the presence of the asymmetric carbon atom.

Submitted on January 4, 1920






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