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Journal of Pharmacology And Experimental Therapeutics, Vol. 149, Issue 3, 446-453, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

TRITIUM-LABELED DIHYDROMORPHINE: ITS METABOLIC FATE AND EXCRETION IN THE RAT

C. C. Hug Jr. 1 and L. B. Mellett 1

1 Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan

Following subcutaneous administration of 5-mg/kg doses of tritium-labeled dihydromorphine (DHM-H3), free and conjugated drug was recovered in urine and feces to the extent of 85% of time dose. A minute fraction of the dose was excreted in the feces as tritium-labeled dihydronormorphine. The data suggested that there are minimal quantitative differences in the metabolism and excretion of DHM-H3 and morphine; qualitatively the biological fate of the two compounds was very similar, if not identical.

Accepted on April 20, 1965






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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.