JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Krakoff, I. H.
Right arrow Articles by Meyer, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Krakoff, I. H.
Right arrow Articles by Meyer, R. L.
Journal of Pharmacology And Experimental Therapeutics, Vol. 149, Issue 3, 417-422, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

INHIBITION OF URIC ACID BIOSYNTHESIS IN THE CHICK EMBRYO AND CHICKEN BY A XANTHINE OXIDASE INHIBITOR, 4-HYDROXYPYRAZOLO(3,4d)PYRIMIDINE

Irwin H. Krakoff 1 and Richard L. Meyer 1

1 Divisions of Clinical and Experimental Chemotherapy, Sloan-Kettering Institute for Cancer Research, New York, N.Y.

Allopurinol, an inhibitor of xanthine oxidase, can markedly inhibit uric acid production in the developing chick embryo, the growing chick and in adult chickens at doses which produce little toxicity. The diversion of nitrogen from the usual end-product, uric acid, to a different nitrogenous end product, continued over a period of several days, is consistent in the chick embryo and chick, with normal development and growth.

Accepted on April 1, 1965






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.