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Journal of Pharmacology And Experimental Therapeutics, Vol. 149, Issue 3, 379-384, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF MEPERIDINE HYDROCHLORIDE AXD MORPHINE SULFATE ON THE LUNG CAPACITY OF INTACT DOGS

Irving Shemano 1 and Herbert Wendel 1

1 Research and Development Division, Smith Kline & French Laboratories, Philadelphia, Pennsylvania

Both meperidine and morphine produced bronchoconstriction in intact dogs at doses ranging from 0.5 to 2.5 mg/kg intravenously. The bronchoconstrictor effects of both morphine and meperidine were markedly reduced by bilateral vagotomy or chlorpheniramine. In the light of past work and present findings, it is probable that morphine and meperidine induce their bronchoconstrictor effects by a combination of central vagal stimulation and histamine release.

Accepted on April 21, 1965






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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.