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Journal of Pharmacology And Experimental Therapeutics, Vol. 149, Issue 3, 358-364, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

HISTOCHEMICAL STUDIES OF THE AUTONOMIC INNERVATION OF THE GUT

David Jacobowitz 1

1 Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

This investigation was designed to study the adrenergic innervation of the gut and to compare the distribution of cholinergic and adrenergic nerves in the enteric tract. The adrenergic innervation of the monkey and cat gut was studied by a histofluorometric method described by Falck (1962). The cholinergic innervation was studied by time thiocholine histochemical method for acetylcholinesterase. The primary adrenergic innervation of the alimentary tract is contained within the myenteric plexus at all levels of the gut. A sparse number of adrenergic nerves is seen in the smooth musculature whereas cholinergic innervation is comparatively dense. Most intramural ganglion cells stain intensely for AChE. Coeliac ganglionectomy of the cat causes a disappearance of those catecholamine-fluorescent nerves innervating the gut. Because of the relatively small number of adrenergic fibers seen in the muscularis externa and the dense accumulation around cholinergic ganglion cells it is suggested that the adrenergic inhibitory mechanism takes place primarily at the myenteric ganglia.

Accepted on April 20, 1965




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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.