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Journal of Pharmacology And Experimental Therapeutics, Vol. 149, Issue 3, 346-350, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

VASCULAR AND METABOLIC EFFECTS OF EPINEPHRINE IN THE ISOLATED PERFUSED RAT LIVER

Albert B. Craig Jr. 1

1 Department of Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, New York

The vascular responses of the isolated perfused rat liver to epinephrine were found to be very similar to that organ's response in vivo, namely a prompt and (lose-dependent vaso-constriction which reduces blood flow. This effect of epinephrine could be blocked or reversed by dihydroergotamine. By contrast, drug-induced potassium and glucose losses from the perfused organ are slow and are less than those which might be expected from this organ in vivo.

Accepted on April 21, 1965






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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.