JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Albuquerque, E. X.
Right arrow Articles by Smith, C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Albuquerque, E. X.
Right arrow Articles by Smith, C. M.
Journal of Pharmacology And Experimental Therapeutics, Vol. 149, Issue 3, 320-328, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

STIMULATION OF MUSCLE SPINDLE AFFERENTS BY DMPP

Edson Xavier Albuquerque 1 and Cedric M. Smith 1

1 Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois

The relationships between dose and effects of intraarterially injected 1, 1-dimethyl-4-phenylpiperazinium iodide (DMPP) on 36 afferent nerves and endings of acutely de-efferented triceps surae muscle spindles of the cat were studied. DMPP produced excitation of all 36 muscle spindle afferent units.

The degree of excitation produced by DMPP was related to the conduction velocity of the afferent fiber: the more rapidly conducting fibers exhibited a greater degree of increase in discharge frequency.

DMPP was less potent than SCh in activating primary afferent endings, but was equal to or more potent than SCh in activating secondary afferent endings.

DMPP was half as potent as SCh and 20 times more potent than nicotine in producing a block of extrafusal neuromuscular transmission.

It is suggested that DMPP acts at the same sites and/or by the same mechanisms as does succinylcholine. The possibility that the mechanism of action of DMPP and succinylcholine is the induction of contracture of certain intrafusal muscle fibers is discussed.

Accepted on April 5, 1965






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.