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Journal of Pharmacology And Experimental Therapeutics, Vol. 149, Issue 2, 161-173, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGICAL AND TOXICOLOGICAL PROPERTIES OF TWO NEW beta-ADRENERGIC RECEPTOR ANTAGONISTS

P. M. Lish 1, J. H. Weikel 1, and K. W. Dungan 1

1 Mead Johnson Research Center, Evansville, Indiana

Studies involving the responses of respiratory and uterine smooth muscle and cardiac muscle to isoproterenol have revealed potent and selective beta-adrenergic blocking action as a property of two phenethanolamine compounds bearing a methylsulfonamido radical at the para position on the benzene ring. These compounds had no other significant peripheral actions, including no local anesthetic action, and only limited effects on the central nervous system. Acute toxicity studies in mice, rats, dogs, and rabbits, and subacute toxicity studies in rats and dogs, indicated extremely low toxic liability. Neither compound had harmful effects on the fetuses of mice or rabbits dosed during critical days of pregnancy.

Accepted on March 15, 1965




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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.