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Journal of Pharmacology And Experimental Therapeutics, Vol. 149, Issue 1, 16-22, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

ENZYMATIC FORMATION OF O-METHYLATED DIHYDROXY DERIVATIVES FROM PHENOLIC AMINES AND INDOLES

Julius Axelrod 1, Joseph K. Inscoe 1, and John Daly 1

1 Laboratory of Clinical Science, National Institute of Mental Health, and Laboratory of Chemistry, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland

Enzymes are described that can metabolize monophenolic amines, N-acetylserotonin, estradiol, phenazocine and phenol to O-methylated dihydroxy derivatives. This reaction takes place in two steps, hydroxylation followed by O-methylation of the dihydroxy metabolite. These enzymes are localized in the liver microsomes and require NADPH for the formation of the dihydroxy compounds and S-adenosyl-methionine for the O-methylation reaction. Species and tissue distribution of the enzymes and the effects of some inhibitors are described.

Accepted on February 22, 1965




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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.