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Journal of Pharmacology And Experimental Therapeutics, Vol. 148, Issue 3, 367-372, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF ETHACRYNIC ACID ON RENAL PROTEIN-BOUND SULFHYDRYL GROUPS

Robert Komorn 1 and E. J. Cafruny 1

1 Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan

Ethacrynic acid reduces the concentration of stainable protein-bound sulfhydryl groups (PBSH) in renal cells of dogs at a time when diuresis is maximal or increasing. Neither a diuresis nor a reduction of PBSH occurs in rats even when the drug is administered intravenously in doses approximately 100 times as large as those effective in dogs.

The data indicate that ethacrynic acid occupies the same chemical "receptors" and may share the same mechanism of action as mercurial diuretics. If reaction of EA with PBSH leads to diuresis, then the site of action of the drug is more extensive than that of mercurials since it lowers PBSH of distal tubular cells as well as PBSH of proximal tubular and collecting duct cells; only the latter two types are influenced when mercurials are used.

Accepted on January 14, 1965






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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.