RENAL HEMODYNAMIC AND ELECTROLYTE EXCRETION EFFECTS OF THE URINARY DIURETIC FACTOR (UDF)

¹ Department of Pharmacology, The Bowman Gray School of Medicine, Winston-Salem, North Carolina

The intravenous injection of the partially purified urinary diuretic factor (UDF) in unanesthetized dogs, in a dose range of 5 to 20 µg/kg, resulted in no significant change in glomerular filtration rate but a significant increase in renal plasma flow. The filtered loads of Na, Cl and K were not increased. The excretion rates for Na and Cl were increased considerably while that for K was increased slightly. The per cent of filtered load reabsorbed for Na and Cl was decreased significantly. The rate of urine flow increased significantly.

The results are interpreted as showing that UDF causes an increased renal plasma flow and a natriuresis with consequent diuresis.