NATRIURETIC AND ANTIGLYCOGENIC ACTIVITIES OF A SERIES OF SYMMETRICAL TRIAZINE AND PTERIDINE DERIVATIVES

¹ Department of Pharmacology and Toxicology, University of Wisconsin, Madison, Wisconsin

A series of 24 symmetrical triazine and 3 pteridine derivatives was examined for natriuretic and antiglycogenic activities in the rat. Diuretically active triazines generally produced natriuresis, kaliuresis, and chioruresis, while the renal responses to the pteridine derivatives were not uniform within the group. The two pteridine derivatives possessing natriuretic activity also inhibited the deposition of hepatic glycogen induced by hydrocortisone.

Two triazine derivatives, 2-amino-4--naphthyl-s-triazine and 2-amino-4-(3,4-dimethoxyphenyl) ethylamino-s-triazine, had significantly more antiglycogenic activity relative to natriuretic activity than chiorazanil, while 2-amino-4-pentylamino-s-triazine had significantly less antiglycogenic than natriuretic activity when compared with chlorazanil.

Methyl and ethyl substitution at the 6- position of ehlorazanil abolished its antiglycogenic action. The resultant compounds caused deposition of glycogen in the livers of adrenalectomized rats. Certain of the compounds in which the amino group at the 4-position of the triazine ring was disubstituted also exhibited glycogenic activity. These findings are interpreted as indicating and further supporting the concept that the observed effects of the triazine derivatives on deposition of hepatic glycogen represent rather specific actions of these compounds.