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Journal of Pharmacology And Experimental Therapeutics, Vol. 148, Issue 3, 298-302, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF ELEDOISIN AND SUBSTANCE P IN THE DOG CROSS CIRCULATION PREPARATION

Hitoshi Kato 1 and Joseph P. Buckley 1

1 Department of Pharmacology, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania

Certain cardiovascular effects of biogenic peptides, eledoisin and substance P, have been studied in dog cross circulation preparations, especially whether these polypeptides induce these effects through central mechanisms. Eledoisin in doses of 0.05 µg/kg showed no cardiovascular action of central origin and produced a powerful vasodilating effect on the area where injected and circulated. Substance P in doses of 1.5 units/kg induced effects very similar to eledoisin.

Accepted on January 14, 1965






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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.