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Journal of Pharmacology And Experimental Therapeutics, Vol. 148, Issue 2, 262-269, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF AUTONOMIC DRUGS ON RENAL TUBULAR TRANSPORT OF CATECHOLAMINES IN THE CHICKEN

Barbara R. Rennick 1 and Marilyn Z. Pryor 1

1 Department of Physiology, Mount Holyoke College, South Hadley, Massachusetts

Renal tubular transport of epinephrine (EPI) , norepinephrine (NOR) , dopamine (DOP) , and metanephrine (MET) occurred in the hen. EPI was transported by the organic acid transport pathway; however, NOR and DOP occupied both the acid and base transport pathways. MAO inhibitors and other autonomic drugs inhibited this transport. Accumulation of EPI and NOR occurred in renal slices and this uptake was inhibited by autonomic drugs.

Accepted on January 12, 1965






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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.