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Journal of Pharmacology And Experimental Therapeutics, Vol. 148, Issue 2, 215-217, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

THE INOTROPIC ACTION OF d-ALDOSTERONE ON PAPILLARY MUSCLES ISOLATED FROM MONKEYS

Winifred G. Nayler 1

1 Baker Medical Research Institute, Melbourne, Victoria, Australia

The inotropic action of d-aldosterone on monkey isolated papillary muscles was investigated. The results obtained show that the immersion of such papillary muscles in Tyrode solution containing 1 x 10-4 to 1 x 10-4 µg/ml d-aldosterone resulted in a sustained positive inotropic response. The augmented contractions were not associated with a changed duration of contraction. The presence of 1 x l0-4 µg/ml d-aldosterone depressed the contractions of other monkey papillary muscle preparations.

The positive inotropic action of d-aldosterone was not blocked by prior treatment of the papillary muscles with the, beta-adrenergic blocking drug, pronethalol.

Accepted on January 12, 1965






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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.