JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fujimori, H.
Right arrow Articles by Cobb, D. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fujimori, H.
Right arrow Articles by Cobb, D. P.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*AMPHETAMINE
*CHLORAZINE
*CHLORDIAZEPOXIDE
*CHLORPROMAZINE
*MEPROBAMATE
*PHENOBARBITAL
*SECOBARBITAL
Journal of Pharmacology And Experimental Therapeutics, Vol. 148, Issue 2, 151-157, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

CENTRAL NERVOUS SYSTEM DEPRESSANT ACTIVITY OF MA1337, 3-[3-(4-m-CHLOROPHENYL-l-PIPERAZYL)PROPYL]-2,4(1H,3H)QUINAZOLINEDIONE HYDROCHLORIDE

Hiroshi Fujimori 1 and Donald P. Cobb 1

1 Chemical Therapeutics Research Laboratory, Miles Laboratories, Inc., Elkhart, Indiana

In a battery of tests, MA1337, a newly synthesized quinazolinedione derivative, was found to have central nervous system depressant activity at doses ranging from 0.06% to 1.9% of its acute LD50 in mice and rats. The dose-response curves of central depressant activity of MA1337 were flat. A blind cross-over behavioral observation in chronic dogs and cats for evaluation of central nervous system activity is described.

Accepted on January 6, 1965






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.