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Journal of Pharmacology And Experimental Therapeutics, Vol. 148, Issue 2, 137-143, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

THE ROLE OF THIAMINE IN NERVOUS TISSUE: EFFECT OF ANTIMETABOLITES OF THE VITAMIN ON CONDUCTION IN MAMMALIAN NONMYELINATED NERVE FIBERS

Christine J. Armett 1 and Jack R. Cooper 1

1 Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut

The effects of two antimetabolites of thiamine, pyrithiamine and oxythiamine, on the electrical activity of the nonmyelinated fibers in the desheathed rabbit vagus nerve have been examined. Pyrithiamine increased the amplitude of both the diphasic action potential recorded through external platinum electrodes and the monophasic action potential recorded in the sucrose-gap apparatus. In addition, pyrithiamine reversed the hyperpolarization produced in these fibers after a tetanus had been applied to the nerve. Oxythiamine, by contrast, was without effect. The difference in action of these two antimetabolites has been ascribed to differences in their transport; it has been shown here that oxythiamine does not penetrate into the particulate fraction of the nerve whereas pyrithiamine does. Other thiamine antimetabolites have been found ineffective in this preparation.

Accepted on January 8, 1965




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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.