NICOTINE-LIKE STIMULANT ACTIONS OF SEVERAL SUBSTITUTED PHENYLCHOLINE ETHERS

¹ Department of Pharmacology, University of Mississippi School of Medicine, Jackson, Mississippi

A number of 3-substituted phenyleholine ethers were prepared and their nicotine-like stimulant action determined. The ethers were assayed using the vasopressor response of the atropinized dog and spinal cat and the cat superior cervical ganglia-nictitating membrane preparation. The order of activity (molar basis) was as follows: I > NH₂ > Br Cl > F H > NO₂. The observed order suggested that the inductomeric effect of the substituents is one important factor determining the intensity of action of these ethers. Several possible mechanisms of action at the receptor level are briefly discussed.