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Journal of Pharmacology And Experimental Therapeutics, Vol. 148, Issue 1, 22-28, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

SUBCELLULAR DISTRIBUTION OF SOME SYMPATHOMIMETIC AMINES AND THEIR beta-HYDROXYLATED DERIVATIVES IN THE RAT HEART

Jose M. Musacchio 1, Irwin J. Kopin 1, and Virginia K. Weise 1

1 Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, U. S. Department of Health, Education and Welfare, Bethesda, Maryland

The subcellular distribution of tyramine, agr- methyltyramine, m-tyramine, dopamine and their beta-hydroxylated derivatives has been studied in the rat heart.

Tyramine, agr-methyltyramine and m-tyramine can enter the microsomal fraction but are not retained. Octopamine, agr-methyloctopamine, m- octopamine, dopamine and norepinephrine are distributed differently between microsomal and soluble fractions. The presence of a catechol group results in greater retention in the microsomal fraction than does the beta-hydroxyl group. Sympathomimetic amines which lack both the catechol and beta-hydroxyl group do not stay in the microsomal fraction. Norepinephrine, which contains both, is most efficiently retained in the particulate fraction.

Retention in the microsomal fraction isolated from tissue homogenates parallels retention of the amine after administration of tyramine or guanethidine.

Accepted on December 21, 1964




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P. Molinoff and J. Axelrod
Octopamine: Normal Occurrence in Sympathetic Nerves of Rats
Science, April 25, 1969; 164(3878): 428 - 429.
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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.