STUDIES ON THE MECHANISMS OF DRUG MOVEMENT FROM THE ISOLATED URINARY BLADDER

¹ Department of Pharmacology, Medical College of Virginia, Richmond, Virginia

The movement of salicylic acid, pentobarbital, nicotine and quinine across the wall of the isolated urinary bladder of the rabbit has been demonstrated. Drug movement was not influenced by the presence of other drugs, by pretreatment of the bladder with metabolic inhibitors, or by changes in temperature. However, changes in the pH of the solution did affect the rate of drug transfer. This transfer of drugs across the bladder wall appears to be mainly passive diffusion of the nonionized form. The ionized form is also transferred by a passive mechanism.