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Journal of Pharmacology And Experimental Therapeutics, Vol. 148, Issue 1, 106-110, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

A BIPHASIC ACTION OF OUABAIN ON SODIUM TRANSPORT IN THE TOAD BLADDER

Thomas K. McClane 1

1 Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, Florida

Ouabain at low concentrations was shown to stimulate the transport of Na+ in the isolated toad bladder as measured by the short-circuit current. At higher concentrations it inhibited the SCC. Increasing the K+ concentration to 14 mM antagonized the inhibitory effect of ouabain, but this higher level of K+ appeared to enhance slightly the stimulatory effect of a lower concentration of ouabain although the significance of the difference was statistically questionable.

Accepted on December 8, 1964






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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.