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Journal of Pharmacology And Experimental Therapeutics, Vol. 147, Issue 3, 391-398, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

ANTIHISTAMINES AND TERATOGENICITY IN THE RAT

C. T. G. King 1, S. A. Weaver 1, and S. A. Narrod 1

1 National Institute of Dental Research, National Institutes of Health, Public Health Service, Department of Health, Education and Welfare, Bethesda, Maryland

The teratogenic potential of two groups of histamine inhibitors was investigated in rats. It was found that antihistamines with ethylamine grouping present as straight chains did not inhibit nidation or induce congenital malformations of any kind while the ones with the ethylamine grouping present as a ring structure (meclizine and chlorcyclizine) had a strong teratogenic potential inducing a specific array of malformations but did not inhibit implantation of the fertilized ova. Norchlorcyclizine, a metabolite of these compounds, is also able to induce the same array of malformations and is probably, therefore, the moiety responsible for their teratogenic effects.

The results emphasize the fact that chronic administration of a drug (chlorcyclizine) will not necessarily yield the same teratogenic effects as acute administration.

Accepted on November 16, 1964




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