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Journal of Pharmacology And Experimental Therapeutics, Vol. 147, Issue 3, 385-390, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

ETHANOL METABOLISM IN CHRONIC PROTEIN DEFICIENCY

R. S. Horn 1 and R. W. Manthei 1

1 Department of Pharmacology, The Jefferson Medical College, Philadelphia, Pennsylvania

The influence of chronic protein deficiency upon ethanol metabolism was studied. Weanling male rats were fed either a semisynthetic diet containing 8% casein as the sole protein source or a control diet which differed only in protein and carbohydrate content. Following a 2-month feeding period, it was shown that the protein depleted rats metabolized ethanol more slowly than animals fed the control diet. Both NAD levels and liver alcohol dehydrogenase activity were below control values in the rats fed the deficient diet. We believe that the decrease in the rate of ethanol metabolism resulted primarily from decreased levels of liver alcohol dehydrogenase in the protein depleted rats.

Accepted on November 16, 1964






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