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1 Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Sympathetic denervation of the rat pineal gland causes an elevation of 5-hydroxytryptophan decarboxylase activity in this gland. The pineal glands of rats kept in constant light environments have about twice as much 5-hydroxytryptophan decarboxylase activity as the pineal glands of litter-mates kept in constant darkness. Blinding or sympathetic denervation prevents the elevating effect of constant light exposure on this enzymatic activity. Bretylium, but not guanethidine blocks the increase in 5-hydroxytryptophan decarboxylase activity in pineals of rats kept in constant light. Exposure of rats to continuous light causes a reduction in pineal weight. Bretylium and guanethidine block this reduction in weight.
Accepted on November 5, 1964
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