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Journal of Pharmacology And Experimental Therapeutics, Vol. 147, Issue 3, 330-335, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

FACILITATION OF GANGLIONIC RESPONSES AFTER A PERIOD OF PREGANGLIONIC STIMULATION

U. Trendelenburg 1 and Ann Jones 1

1 Department of Pharmacology, Harvard Medical School, Boston, Massachusetts

A short period of preganglionic stimulation (5 seconds at a rate of 25 shocks/second) greatly enhances the subsequent response of the superior cervical ganglion of the cat to the muscarinic agent McN-A-343; this facilitation lasts for more than an hour. Ganglionic responses to histamine were equally enhanced, those to nicotine were slightly enhanced, while there was no effect of preganglionic stimulation on the subsequent response of the ganglion to potassium chloride.

Facilitation of the ganglionic response to McN-A-343 was not produced by postganghonic stimulation. Hexamethonium blocked the response of the ganglion to preganglionic stimulation but did not interfere with the facilitation of McN-A-343 by this stimulation.

Neither atropine alone nor the combination of atropine with hexamethonium antagonized the facilitation by preganglionic stimulation of the ganglionic effect of histamine. Morphine failed to antagonize the facilitatory effect of preganglionic stimulation on the response of the ganglion to nicotine.

Intraarterial injections of acetylcholine and nicotine failed to produce an enhancement of subsequent injections of McN-A-343 to the ganglion.

Accepted on November 10, 1964






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