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Journal of Pharmacology And Experimental Therapeutics, Vol. 147, Issue 2, 232-235, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

QUANTITATIVE RELATIONSHIP OF MOTOR ACTIVITY AND OXYGEN CONSUMPTION IN MICE

Helmut M. Redetzki 1

1 Department of Pharmacology, Louisiana State University, School of Medicine, New Orleans, Louisiana

A method was described for simultaneous measurement of motor activity and oxygen consumption of mice. It used a closed system spirometer adapted for continuous recording. A phonograph cartridge attached to the bottom of the animal chamber served as movement detector. Quantification of motor activity was obtained from Playback of the tape recorded impulses into an isotope scaler for digital readout. From records of 48 pairs of mice a linear relationship between oxygen consumption and the log10 of motor activity was obtained and statistically analyzed by regression analysis. The data provide a basis against which drug effects can be easily evaluated.

Accepted on October 21, 1964






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