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Journal of Pharmacology And Experimental Therapeutics, Vol. 147, Issue 2, 225-231, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

PROTECTIVE ACTION OF QUINDONIUM BROMIDE (W3366A) AGAINST HEMORRHAGE SHOCK IN DOGS

Melville W. Osborne 1, Howard M. Rowe 1, Richard N. Kaufman 1, Melvin C. Johnson 1, Wilhelmina Willems 1, and Martin M. Winbury 1

1 Department of Pharmacology, Warner-Lambert Research Institute, Morris Plains, New Jersey

Prophylactic administration of quindonium (10 mg/kg) 15 minutes before hemorrhage produced a significant increase in survival rate of dogs exposed to hemorrhage stress. Other quindonium dose levels and sequence of administration did not produce significant survival rates. Treatment with quindonium did not alter animal tolerance to hemorrhage stress by inducing a prehemorrhage increase in plasma volume. Treated animals, as compared to control animals, showed significant decreases in heart rate, vasodilatation during hemorrhage and reinforcement of myocardial force of contraction during and after hemorrhage. It is postulated that during hemorrhage quindonium reinforces compensatory homeostatic mechanisms which afford resistance to the noxious effects of prolonged sympathetic discharge.

Accepted on October 20, 1964






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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.