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Journal of Pharmacology And Experimental Therapeutics, Vol. 147, Issue 2, 181-185, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

EVIDENCE FOR EXTRANEURONAL BINDING OF NOREPINEPHRINE

Josef E. Fischer 1, Irwin J. Kopin 1, and Julius Axelrod 1

1 Laboratory of Clinical Science, National Institutes of Health, National Institute of Mental Health, U. S. Department of Health, Education and Welfare, Bethesda, Maryland

A small amount of H3-norepinephrine is taken up by the chronically denervated salivary gland. This extraneuronal store is released rapidly at first and then more slowly. In contrast to the intact salivary gland, reserpine has no effect on the uptake or release of norepinephrine from the denervated gland. Tyramine can release a small portion of the extraneuronal H3-norepinephrine. Reserpine blocks the uptake of H3-norepinephrine, and decentralization retards the release of H3-norepinephrine from sympathetic ganglia. The extraneuronal store of norepinephrine does not appear to reside in " floating ganglia."

Accepted on October 13, 1964






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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.