JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smith, C. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith, C. B.
Journal of Pharmacology And Experimental Therapeutics, Vol. 147, Issue 1, 96-102, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF d-AMPHETAMINE UPON BRAIN AMINE CONTENT AND LOCOMOTOR ACTIVITY OF MICE

Charles B. Smith 1

1 Department of Pharmacology, Harvard Medical School, Boston, Massachusetts

d-Amphetamine, cocaine and pipradrol increased the locomotor activity of groups of five mice. Although both cocaine and pipradrol caused greater increases in locomotor activity than those attained with d-amphetamine, only d-amphetamine caused significant changes in brain norepinephrine, dopamine or 5-HT levels at doses which increased locomotor activity. These results indicate that changes in brain amines caused by d-amphetamine are neither secondary to the activity-increasing effects of d-amphetamine nor result from a nonspecific action of drugs which increase locomotor activity. Changes in locomotor activity caused by d-amphetamine were not correlated closely with changes in the brain content of norepinephrine, dopamine or 5-HT. Small doses of d-amphetamine increased brain dopamine levels. Larger doses decreased the brain content of norepinephrine and increased the brain content of 5-HT. Pretreatment of mice with either iproniazid or reserpine enhanced the activity-increasing effect of d-amphetamine.

Accepted on September 13, 1964




This article has been cited by other articles:


Home page
 ScienceHome page
K. M. Taylor and S. H. Snyder
Amphetamine: Differentiation by d and I Isomers of Behavior Involving Brain Norepinephrine or Dopamine
Science, June 19, 1970; 168(3938): 1487 - 1489.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
A. H. Anton and M. Greer
Dextroamphetamine, Catecholamines, and Behavior: The Effect of Dextroamphetamine in Retarded Children
Arch Neurol, September 1, 1969; 21(3): 248 - 252.
[Abstract] [PDF]

Home page
 ScienceHome page
D. Holtzman, R. A. Lovelil, J. H. Jaffe, and D. X. Freedman
1-dgr9-Tetrahydrocannabinol: Neurochemical and Behavioral Effects in the Mouse
Science, March 28, 1969; 163(3874): 1464 - 1467.
[Abstract] [PDF]

Home page
 ScienceHome page
J. J. Schildkraut and S. S. Kety
Biogenic Amines and Emotion
Science, April 7, 1967; 156(3771): 21 - 30.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.