JPET Celsis microsomes equal better data

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Journal of Pharmacology And Experimental Therapeutics, Vol. 147, Issue 1, 40-47, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF LOCAL ANESTHETICS ON SODIUM AND POTASSIUM IN HUMAN RED CELLS

Nikaan B. Andersen 1 and J. S. Gravenstein 1

1 Division of Anesthesiology, College of Medicine, University of Florida, Gainesville, Florida

The active uptake of potassium and elimination of sodium by human erythrocytes incubated at 37°C after 6 days of cold storage were diminished by clinically used concentrations of procaine, dibucaine, cocaine, lidocaine, and tetracaine. These local anesthetics caused, especially in the higher concentrations, hemolysis and increased the passive loss of potassium from the cell and leak of sodium into the cell.

Accepted on October 2, 1964






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Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics.