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*HYDROGEN PEROXIDE
*PHENYLHYDRAZINE
*PRIMAQUINE
Journal of Pharmacology And Experimental Therapeutics, Vol. 147, Issue 1, 139-143, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

IN VIVO GENERATION OF H2O2 IN MOUSE ERYTHROCYTES BY HEMOLYTIC AGENTS

Gerald Cohen 1 and Paul Hochstein 1

1 Departments of Biochemistry and Psychiatry, Columbia University College of Physicians and Surgeons, and The New York State Psychiatric Institute, New York, N. Y.

3-Amino-1,2,4-triazole (AT) was employed as a tracer to detect H2O2 within the erythrocytes of mice. H2O2 was clearly detected after administration of phenylhydrazine or menadione; for pamaquine, primaquine or aniline, the results were less definitive but still indicative of increased intracellular H2O2 levels. These results support the view that H2O2 toxicity plays a major role in drug-induced hemolysis of glucose-6-phosphate dehydrogenase-deficient erythrocytes.

Accepted on October 2, 1964




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