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Journal of Pharmacology And Experimental Therapeutics, Vol. 147, Issue 1, 112-119, 1965
Copyright © 1965 by American Society for Pharmacology and Experimental Therapeutics

MORPHOLOGICAL CHANGES IN THE LIVER ACCOMPANYING STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITY BY PHENOBARBITAL, CHLORDANE, BENZPYRENE OR METHYLCHOLANTHRENE IN RATS

James R. Fouts 1 and Larry A. Rogers 1

1 Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City, Iowa

Hepatic microsomal drug metabolizing enzyme activity and hepatic ultrastructure have been studies in rats treated with phenobarbital, chlordane, benzpyrene, or methylcholanthrene. These studies have allowed a classification of these stimulators of drug metabolism into groups: phenobarbital and chlordane vs. benzpyrene and methylecholanthrene. Phenobarbital and chlordane stimulate a variety of microsomal drug metabolisms and also appear to cause a marked proliferation of smooth-surfaced endoplasmic reticulum (SER) in the hepatic cell. Benzpyrene and methylcholanthrene stimulate only a few microsomal drug metabolizing enzymes and do not appear to cause any pronounced increase in hepatic cell SER.

Accepted on September 13, 1964




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