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Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 3, 400-403, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

BENZQUINAMIDE AND THE 5-HYDROXYTRYPTAMINE RECEPTORS IN GUINEA-PIG TRACHEA

Jay W. Constantine 1 and Cynthia Knott 1

1 Department of Pharmacology, Medical Research Laboratories, Chas. Pfizer & Co., Inc., Groton, Connecticut

Benzquinamide was a specific antagonist of 5-HT on isolated guinea-pig trachea but not on guinea-pig ileum. The compound inhibited 5-ITT on rat uterus although not in a concentration-related manner. Benzquinamide was a surmountable antagonist to 5-HT-induced bronchoconstriction in the intact guinea pig. The effect of 5-HT on guinea-pig trachea did not depend upon the activation of a cholinergic mechanism as it does, in part, in guinea-pig ileum. The 5-HT receptors in guinea-pig trachea resemble "D" (muscle) receptors in that they were not blocked by atropine or by morphine, but were blocked by methysergide.

Accepted on September 2, 1964






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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.