CIRCULATORY RESPONSES TO INTRAVENOUS INFUSIONS OF HYDROXYETHYL STARCH SOLUTIONS

¹ Department of Pharmacology and Therapeutics, Medical College of South Carolina, Charleston, South Carolina

Circulatory responses to various replacement fluids were compared following their administration to dogs which had been subjected to severe bleeding. Medium molecular weight (75,000) dextran, Tyrode saline, fresh autologous heparinized blood and stored homologous citrated whole blood were compared with a starch derivative previously selected on the basis of intravascular persistence and tissue compatibility. This derivative, hydroxyethyl starch, was prepared from a waxy sorghum starch, containing largely the branched fraction, amylopectin, which had been acid-degraded to ‘90-fluidity," gelatinized and then derivatized with one hydroxyethyl group attached to 90% of the anhydroglucose residues (90 degrees of substitution). After replacement of withdrawn blood volumes, arterial pressures and plasma volumes were lowest in the instance of Tyrode saline solutions, while blood was intermediate between saline solution and colloid solutions in this respect. Significant differences among the colloid solutions were not observed in measurements of buffering capacities, hematocrit values, erythrocyte sedimentation rates or ECG recordings.

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