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Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 3, 307-312, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF OUABAIN ON POTASSIUM EXCHANGE IN SKELETAL MUSCLE

D. R. H. Gourley 1 and Margaret D. Bethea 1

1 Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia

The effects of ouabain on the unidirectional fluxes of K were measured in the isolated sartorius muscle of the frog. Ouabain decreased the uptake of K by muscles in normal Ringer solution and increased the K efflux rate constant in muscles in K-free Ringer solution. Ouabain had no significant effect on K effiux in isotonic sucrose solution. The inhibition of K influx by ouabain was competitive and it is suggested that ouabain complexes with carrier molecules at the outer surface of the membrane thus reducing the number of carriers available to participate in the active cation transport cycle. The conflicting observations of the effect of ouabain on K efflux under different experimental conditions were tentatively explained in terms of the carrier hypothesis.

Accepted on August 12, 1964




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