JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rogers, L. A.
Right arrow Articles by Fouts, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rogers, L. A.
Right arrow Articles by Fouts, J. R.
Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 3, 286-293, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

SOME OF THE INTERACTIONS OF SKF 525-A WITH HEPATIC MICROSOMES

Larry A. Rogers 1 and James R. Fouts 1

1 Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City, Iowa

SKF 525-A was shown to decrease hepatic glycogen levels and inhibit microsomal metabolism of hexobarbital, aminopyrine, and codeine for periods up to 24 hours. Chemical and enzymic assays show that SKF 525-A is strongly bound to hepatic microsomes and is not removed by dialysis or washing of these particulates against or with 1.15% KCl or soluble fraction from normal liver. This is in contrast to results obtained with another microsomal enzyme inhibitor, iproniazid. Iproniazid does not seem to be strongly bound to microsomes and its inhibition of microsomal enzymes is reversed by dialysis or washing of microsomes. The concentration of SKF 525-A in liver from animals treated with this compound declines rapidly between 1 and 12 hours after its administration, yet the amount of enzyme inhibition during this period remains essentially unchanged. Indirect evidence indicates that a metabolite of SKF 525-A may be involved in inhibition of microsomal reactions.

Accepted on September 13, 1964




This article has been cited by other articles:


Home page
 ScienceHome page
L. Diamond and H. V. Gelboin
Alpha-Naphthoflavone: An Inhibitor of Hydrocarbon Cytotoxicity and Microsomal Hydroxylase
Science, November 21, 1969; 166(3908): 1023 - 1025.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.