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Journal of Pharmacology And Experimental Therapeutics, Vol. 146, Issue 3, 280-285, 1964
Copyright © 1964 by American Society for Pharmacology and Experimental Therapeutics

SIMILARITIES BETWEEN OXIDATIVE DRUG-METABOLIZING ENZYMES AND STEROID HYDROXYLASES IN LIVER MICROSOMES

R. Kuntzman 1, M. Jacobson 1, K. Schneidman 1, and A. H. Conney 1

1 The Wellcome Research Laboratories, Burroughs Wellcome & Co. (U.S.A.) Inc., Tuckahoe, New York

Liver microsomal enzymes oxidatively metabolize steroids and foreign compounds in the presence of TPNH and oxygen to compounds which are more polar than the substrate. Factors such as sex, age, species and the administration of drugs alter the in vitro metabolism of drugs and steroids. The similar properties exhibited by the enzymes which metabolize both steroids and drugs suggest that steroid hormones are normally occurring substrates for oxidative drug-metabolizing enzymes in liver microsomes.

Accepted on August 7, 1964




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Copyright © 1964 by the American Society for Pharmacology and Experimental Therapeutics.